In the 21st century, more than ever, our decisions are driven by scientific research. Whether it’s energy and climate policy, health care, marketing practices, or investment decisions, we rely consciously and unconsciously on scientific research to guide us. But shockingly, up to half of what’s published in peer-reviewed journals and then reported unquestioningly by the mass media is in some way flawed. What, if anything, can be done to correct this problem? More importantly, what can decision makers do to ensure that they — and the stakeholders they represent — aren’t duped? The Trends editors examine these questions and provide some valuable guidance.