The panic du jour crowd inevitably makes every new threat, from Ebola to climate change, into an “unprecedented crisis.” Prior to the 21st century, there was usually too little data and analytic capability to quantify the most significant threats. But increasingly, big data and advanced computing technologies have extended our ability to understand complex causal relationships and test “what-if” hypotheses. That obviously applies to run-of-the-mill policy decisions like entitlements, taxation, and regulations. It even extends to identifying existential threats to human survival as well as their likelihood, causation, and prevention. What are the biggest threats to human civilization surviving the next century? What is the realistic likelihood of each threat? How should we respond? We’ll provide preliminary answers to each of these questions.